I do not want to confuse @jsteiwer, so this is more for @bns: The buck-boost I linked uses a TPS63070 or a clone of this chip. The datasheet of the TPS63070 states that the enable pin must not be left floating. So, the board needs to use a pull-up resistor. I have some of these cheap modules in my lab. If I wanted to use these in low standby power applications, I would simply remove the pull-up resistor and connect the ENABLE pin (of the module) to GND via a high-value resistor. An additional connection to the ENABLE pin could then be used to switch the module on and off. So, DIY off-by-default is very easy.
EDIT: In case you want to do this with exactly this model: Remove the resistor marked in red. It is 10 kOhm. But this module uses a tantalum input capacitor, it might go up in flames.